Analysis of VH gene expression in CD5+ and CD5- B-cell chronic lymphocytic leukemia
نویسندگان
چکیده
منابع مشابه
Analysis of VH gene expression in CD5+ and CD5- B-cell chronic lymphocytic leukemia.
In contrast to highly mutated follicular lymphomas and multiple myelomas, chronic lymphocytic leukemias (CLLs) frequently express VH genes in germline configuration. It is currently unclear whether this difference is related to the expression of CD5 or to the differentiation stage of the B cell when malignant transformation occurs. We have studied the VH sequence of 11 cases of CD5- B-CLL to ad...
متن کاملAnalysis of VH Gene Expression in CD5+ and CD5- B-Cell Chronic Lymphocytic Leukemia
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We studied the expression of CD5 and immunoglobulin variable gene families in a panel of monoclonal Epstein-Barr virus (EBV) transformed lines, chronic lymphocytic leukemias (CLLs) and CD5+ and CD5- B-cell lymphomas. The CD5 gene expression was in all cases identical to that of T-cell malignancies. The utilization of the various VH and VK gene families was roughly proportional to the estimated ...
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The human leukocyte antigen G (HLA-G) molecule exhibits limited tissue distribution, low polymorphism and alternative splicings that generate seven HLA-G isoforms. HLA-G exerts multiple immunoregulatory functions. Recent studies indicate an ectopic up-regulation in tumor cells that may favor their escape from anti-tumor immune responses. This study it is an effort to clarify the presence of HLA...
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ژورنال
عنوان ژورنال: Blood
سال: 1995
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v86.10.3883.bloodjournal86103883